app.ivive/ivive·Science

ivive.app

Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.

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remote

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$claude mcp add --transport http ivive https://api.ivive.app/mcp/

Nothing to configure — it works as is.

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Reviewed 41m ago.

No findings.

predict_inputs
Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.
calc_clhep
Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.
target_clint
The in-vitro CLint an assay must read for a compound to reach a target plasma clearance.
input_sensitivity
How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.
similar_drugs
Most similar reference drugs to a SMILES, with observed and IVIVE-predicted clearance: how IVIVE fared on this kind of structure.
scale_to_human
Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.